The function of each cell and each organism decisively depends on the dynamic interactions between biological macromolecules and on their correct three-dimensional structure. Faulty interaction and incorrectly folded structures eventually lead to diseases and ageing. Our aim is to understand these interactions and to determine the three-dimensional structure of the protein complexes involved in decisive cellular processes - if possible, in atomic resolution.
We use atomic resolution methods like x-ray crystallography, NMR spectroscopy, molecular dynamics simulation and cryo electron microscopy. In addition, we apply all available methods for quantitative characterization of interactions, like ITC, BLI, SPR and switch SENSE.