Bioeconomy Science Center
Forschung und Kooperation für nachhaltige BioÖkonomie

Bioeconomy Science Center
Forschung und Kooperation für nachhaltige BioÖkonomie
BOOST FUND Projekt PNP-EXPRESS

Discovery and microbial production of natural products from plants

Results

The conversion of plant-derived biomass to high-value products such as nutrients, fine chemicals, pharmaceutical building blocks or natural products with pharmaceutical activities is the key towards a sustainable bioeconomy. For this purpose, versatile microbial platform organisms for the production of such compounds are needed. This project aims to develop microbial cell factories with an emphasis on the production of plant natural products (PNPs). The construction of microbial cell factories requires the effective construction of artificial metabolic pathways and compatibility between bacterial and plant biosynthetic pathways PNP-Express aims to develop: (i) bioinformatics tools and databases for the reliable identification of pathways for PNPs in plant genomes and (ii) microbial platform strains with increased PNP-precursor levels through metabolic engineering.

Participating Core Groups

Prof. Dr. Michael Bott, Dr. Jan Marienhagen, Institut für Bio- und Geowissenschaften; IBG-1: Biotechnologie, Systemische Mikrobiologie, Forschungszentrum Jülich GmbH
Prof. Dr. Karl-Erich Jaeger, Dr. Thomas Drepper, Institut für Molekulare Enzymtechnologie (IMET), Heinrich-Heine-Universität Düsseldorf
Prof. Dr. Björn Usadel, Lehrstuhl für Botanik und Institut für Biologie I, RWTH Aachen University

Coordinator
Prof. Dr. Michael Bott

Forschungszentrum Jülich GmbH
Institute of Bio- and Geosciences
IBG-1: Biotechnology
52425 Jülich
Phone: +49 2461 61-3294
Fax: +49 2461 61-2710
email: m.bott@fz-juelich.de


Funding period

01.01.2014 – 31.12.2015


Funding
The total budget of PNP-EXPRESS is € 427,680.00. PNP-EXPRESS is part of the NRW-Strategieprojekt BioSC and thus funded by the Ministry of Innovation, Science and Research of the German State of North Rhine-Westphalia.


Publications

Hartl, K, Denton, A, Franz-Oberdorf, K, Hoffmann, T, Spornraft, M, Usadel, B and Schwab, W (2017). Early metabolic and transcriptional variations in fruit of natural white-fruited fragaria vesca genotypes. Sci Rep 7: 45113.

Lang, V, Usadel, B and Obermeyer, G (2015). De novo sequencing and analysis of the lily pollen transcriptome: An open access data source for an orphan plant species. Plant Mol Biol 87(1-2): 69-80.

van Summeren-Wesenhagen, PV and Marienhagen, J (2015). Metabolic engineering of escherichia coli for the synthesis of the plant polyphenol pinosylvin. Appl Environ Microbiol 81(3): 840-849.

van Summeren-Wesenhagen, PV, Voges, R, Dennig, A, Sokolowsky, S, Noack, S, Schwaneberg, U and Marienhagen, J (2015). Combinatorial optimization of synthetic operons for the microbial production of p-coumaryl alcohol with escherichia coli. Microb Cell Fact 14: 79.

Wang, H, Paulo, J, Kruijer, W, Boer, M, Jansen, H, Tikunov, Y, Usadel, B, van Heusden, S, Bovy, A and van Eeuwijk, F (2015). Genotype-phenotype modeling considering intermediate level of biological variation: A case study involving sensory traits, metabolites and qtls in ripe tomatoes. Mol Biosyst 11(11): 3101-3110.