At present, industrial bioprocesses are predominantly based on a “one substrate – one product” concept. The implementation of a sustainable bioeconomy that is competitive with respect to ecologic and economic demands will, however, critically depend on novel highly interwoven value networks based on “multi substrate – multi product” processes in biorefineries. Establishing such processes requires the tight integration of microbial biotransformations, enzymatic cascade reactions, chemical synthesis steps, product recovery and techno-economic analysis, denoted as “hybrid processes”. HyImPAct aims at a major breakthrough in this field by designing a complex hybrid example process for the combined production of active pharmaceutical ingredients (chiral 1,2-diols, amino alcohols) and their bulk chemical precursor, starting from D-xylose as the major carbon source of lignocellulosic hydrolysates. Corynebacterium glutamicum will serve as a platform organism and further engineered towards the utilization of D-xylose containing feedstocks with minimized carbon loss. Process development will be based on a set of recently demonstrated bio- and chemo transformations. The work will be accompanied by profound techno-economic analyses, focusing on the comparison between established vs. proposed alternative production routes. These tasks include the development of new approaches (models and tools) for the design, evaluation and optimization of hybrid processes.
Bioeconomy is concerned with the transformation of an oil-based into a sustainable economy based on renewable resources. However, classical chemical industry based on petrochemical resources has matured over one century and, thus, is highly optimized for economic efficiency. Due to the highly interwoven nature of classical chemical processing steps, it is not very probable that bioeconomic value networks will grow beneath classical chemical syntheses and someday will just replace it. The challenge is the transition to hybrid value networks and the stepwise “infiltration” of classical value networks by more sustainable and “greener” processes. HyImPAct will focus on one specific, but highly relevant, hybrid example process in which bio-production of bulk chemicals is coupled to enzymatic and chemo transformation steps to finally produce compounds of highly added value. Moreover, by starting from D-xylose as most abundant and renewable carbon source, the hybrid process is envisioned to be sustainable and economically feasible.
Dr.-Ing. Stephan Noack
IBG-1: Biotechnology, Quantitative Microbial Phenotyping
52428 Jülich, Germany
HERBRAND PharmaChemicals GmbH
01.01.2018 – 31.12.2020
The total budget of HyImPAct is € 1.905.990. HyImPAct is part of the NRW-Strategieprojekt BioSC and thus funded by the Ministry of Culture and Science of the German State of North Rhine-Westphalia.
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